“XEC is not very prevalent in the United States right now, but that will likely change if it is indeed more evolutionarily fit than current dominant variants,” says Amesh Adalja, MD, senior scholar with the Johns Hopkins Center for Health Security and a spokesperson for the Infectious Disease Society of America.
How Is XEC Different From the Current Top Variants?
Right now, the coronavirus variant KP3.1.1 (a close relative of other top variants — KP.2, KP.2.3, and KP.3) accounts for about half of the COVID-19 infections in the country.
XEC is different, though, because it is a “recombinant” virus, meaning it incorporates features from two other variants (in this case, KS.1.1 and KP.3.3), explains Peter Chin-Hong, MD, a professor of medicine at the University of California in San Francisco, who specializes in infectious diseases.
He points out that XEC has a mutation in a so-called spike protein that may improve its ability to bind to human cells, which in turn may heighten contagiousness.
Will Vaccines Offer Enough Protection?
Dr. Chin-Hong advises the public to be “curious and vigilant” but not overly worried about XEC: The variant, he says, doesn’t appear to pose a greater health threat than other currently circulating variants.
This is why Chin-Hong and other healthcare providers are emphasizing the importance of vaccination — especially for people who are particularly vulnerable to severe COVID-19 like the elderly or the very immunocompromised. In these groups, immunity from earlier vaccinations or infections will likely have sufficiently worn off by now.
What Are the Symptoms of the XEC Variant?
- Nasal congestion or runny nose
- Sore throat
- Fatigue
- Headache
- Cough
- Muscle or body aches
- Fever or chills
- Nausea or vomiting
- Diarrhea
- New loss of taste or smell
- Shortness of breath or difficulty breathing
When it comes to shortness of breath, Chin-Hong highlights that this symptom seems to appear more frequently in older or immunocompromised individuals who did not get a vaccine in the last year.
XEC Is the Latest But Not the Last COVID Variant We’ll Ever See
The latest variant is certainly not the last, but increasing community immunity, updated vaccinations, and medicines such as Paxlovid and other antivirals make it unlikely that we will see a pandemic-level rise in serious illness as more variants come along, notes Adalja.
“Variants are going to come and go in perpetuity,” he says. “There will always be one variant rising and one falling, basically forever. And respiratory viruses will continually evolve to try and get around some of the immunity that prior infections and vaccinations have engendered.”
